Disable: Calculates all gains and the costs basis from trades only (recommended - as described in this article Different ways of managing your portfolio).

The remaining amount of a coin can deviate from the values in the dashboard, because deposits and withdrawals will not be included.

Enable: Includes all deposits and withdrawals into the calculation.

Gains and the cost basis will change as deposits and withdrawals do not have a cost basis.

This can be changed when you click on "Edit" for the API job. Then you find the options on the left for your specific API key and can change it via the highlighted slider.